A case of pancreatic neuroendocrine tumor exhibiting spontaneous cystic regression and subsequent regrowth

Q: What does this research mean for the field?

Pancreatic neuroendocrine tumors (PNEN) can undergo spontaneous cystic regression followed by regrowth, presenting with histopathological features distinct from typical cystic degeneration. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Daishi Morimoto; Sho ITO; Norito FUTAMURA; Ayaka YOKOI; Shoichiro ITO; Masahiro Sasahara; Toshifumi Murai; Mitsuru Sakai; Shoji HASHIMOTO

doi:10.2958/suizo.41.77

April 30, 2026Suizo

A case of pancreatic neuroendocrine tumor exhibiting spontaneous cystic regression and subsequent regrowth

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Key Points

To report a rare case of spontaneous cystic regression of a pancreatic neuroendocrine tumor followed by regrowth.
Case report of a 51-year-old female with a history of pancreatic tumor and its regression over time.
Diagnostic laparoscopic surgery was performed, followed by pathological examination of the resected tumor.
The initial tumor shrank significantly and almost completely regressed 10 months later.
Regrowth of the tumor was observed at 27 months, with further increase at 55 months.
Pathological examination confirmed the diagnosis of pancreatic neuroendocrine tumor (PNEN) G1.

Implication

A case reports spontaneous cystic regression followed by regrowth of a pancreatic neuroendocrine tumor, suggesting unique pathological properties.

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Cite This Study

Morimoto et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e2f0307b7850943106e https://doi.org/10.2958/suizo.41.77

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A case of pancreatic neuroendocrine tumor exhibiting spontaneous cystic regression and subsequent regrowth

Key Points

Implication

Abstract

Discussion

Cite This Study

A case of pancreatic neuroendocrine tumor exhibiting spontaneous cystic regression and subsequent regrowth

Key Points

Implication

Abstract

Discussion

Cite This Study

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