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May 30, 2026The Journal of Organic Chemistry

Ruthenium(II)-Catalyzed Remote Alkylation of 2-Pyridones via Cleavage of C–H or C–Cl Bonds

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Authors

XLXingchi LiFYFengqi YangZQZhaoyang Qin

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Overview

Randomized trial demonstrates selective alkylation of 2-pyridones, suggesting a novel method for functionalization.

Key Points

  • This research aims to develop a ruthenium(II)-catalyzed method for remote alkylation of 2-pyridones through C–H or C–Cl bond cleavage.
  • Utilized ruthenium(II) catalyst for alkylation reactions
  • Employed nitrogen-directed σ-activation strategy
  • Explored both C–H activation and C–Cl bond cleavage pathways
  • Achieved C5-alkylation and C3,C5-dialkylation of 2-pyridones
  • Demonstrated broad substrate scope and good functional group tolerance
  • Provided operational simplicity for late-stage diversification of 2-pyridone scaffolds

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e6a0307b785094310f0https://doi.org/10.1021/acs.joc.6c00724
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Also Consider

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