Key result
Kailuan cohort tracks major cardiovascular events and deaths to evaluate real-world health interventions.
Why the study?
The study was established to investigate the life-course natural history of non-communicable diseases, identify key risk factors and biomarkers, elucidate underlying pathological pathways, and provide a real-world platform to evaluate interventions.
Cohort (n=170,000)
The Kailuan Study is a large, prospective dynamic cohort in China that provides a real-world evidence platform for evaluating life-course trajectories of non-communicable diseases, particularly cardiovascular events.
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Provides real-world platform for cardiovascular risk tracking in Chinese workers; leaves open causal links for interventions.
Purpose: The Kailuan Study was established to investigate the life-course natural history of non-communicable diseases, identify key risk factors and biomarkers, and elucidate the underlying pathological pathways. Ultimately, this study aims to provide a real-world evidence platform for evaluating health interventions and tailored health management. Participants: Initiated in 2006 in Tangshan, China, this prospective dynamic cohort is embedded within the Kailuan Group, a large industrial functional community with an integrated healthcare system. At baseline, 101,510 adults (aged 18–98 years) were enrolled, and biennial rolling recruitment expanded the cohort to over 170,000 participants. Follow-up is conducted by linking biennial standardized health examinations with annual medical insurance databases and death registries. Findings to date: As of December 2023, the study has captured over 22,000 cardiovascular events, 8,000 cancers, and 24,000 deaths. Research has shifted from cardiovascular to multi-systemic diseases, identifying longitudinal risk trajectories, the temporal ordering of metabolic dysfunction, and the life-course impact of early-life and occupational exposures. Furthermore, the embedded healthcare setting of the cohort supports the evaluation of real-world prevention and management strategies. Future plans: Ongoing follow-up will integrate multi-omics, advanced imaging, and digital phenotyping to support life-course and multimorbidity research. Using artificial intelligence-driven approaches and causal inference frameworks, this study will develop integrated health models for whole-life-cycle-based management and disease control. Registration: The cohort was registered in the Chinese Clinical Trial Registry (ChiCTR-TNRC-11001489 and ChiCTR2000029767).
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Wu et al. (2026) conducted a cohort in Non-communicable diseases (n=170,000). The Kailuan Study prospective cohort of over 170,000 adults has captured over 22,000 cardiovascular events, 8,000 cancers, and 24,000 deaths to evaluate real-world health interventions.
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