October 16, 2024PhenomicsOpen Access

Cohort Profile: TRacing Etiology of Non-communicable Diseases (TREND): Rationale, Progress and Perspective

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Why the study?

The study was designed to decipher comprehensive molecular characterization and deep phenotyping for chronic non-communicable diseases to provide mechanistic insights with diagnostic, prognostic, and therapeutic implications.

Population

3360 participants aged over 18 years in Ma'anshan, Anhui Province, China

Design

Prospective longitudinal cohort and biobank study

Follow-up

A total of 30 years

Authors

HRHuiying RenPacific Northwest National Laboratory YLYing LvNanjing Drum Tower Hospital BMBingxin MaTianjin Medical University

Discussion

Member takes

Implication

Should not change NCD practice yet; leaves open gene-environment mechanisms from this new 20 000-person Chinese family multi-omics cohort.

Structured PICO

Population

3,360 participants (target 20,000) aged over 18 years from urban and rural areas of Ma'anshan, Anhui Province, China, recruited as pairs from households with first-degree linkage. Mean age 59.82 for men and 55.31 for women, 59.6% women.

Outcome

Comprehensive molecular characterization and deep phenotyping for a broad spectrum of chronic non-communicable diseases (NCDs) to provide mechanistic insights.

The TREND cohort provides a comprehensive prospective resource for deep phenotyping and multi-omics to study the etiology of non-communicable diseases in China.

Limitations

Reliance on self-reported data
Selection bias due to single-center nature
Nonparticipation and loss to follow-up
Potential bias from health-conscious individuals adopting specific lifestyles
Potential impact of unmeasured or residual factors

Cite This Study

Ren et al. (2024) studied this question.

synapsesocial.com/papers/6a806592ea50fa4f07928f2b https://doi.org/10.1007/s43657-024-00196-4

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Implication

Should not change NCD practice yet; leaves open gene-environment mechanisms from this new 20 000-person Chinese family multi-omics cohort.

Cohort Profile: TRacing Etiology of Non-communicable Diseases (TREND): Rationale, Progress and Perspective

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Cohort Profile: TRacing Etiology of Non-communicable Diseases (TREND): Rationale, Progress and Perspective

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider