Demonstrates successful C8–H sulfonamidation in isoquinolones, indicating a new method for drug development.
We report a Ru(II)‐catalyzed, directing‐group‐assisted regioselective C8–H sulfonamidation of N ‐aryl and N ‐alkylisoquinolones using sulfonyl azides. The transformation proceeds under mild conditions with excellent regioselectivity. Aryl and polyaromatic sulfonyl azides delivered products in good to excellent yields. This protocol affords access to pharmaceutically relevant C8‐sulfonamidated isoquinolones.
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Kumari et al. (2026) studied this question.
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