Imine-Directed Ru(II)-Catalyzed ortho-C(sp²)–H Amidation of 3-Arylquinoxalin-2(1H)-ones via Nitrene Transfer from Acyl/Heteroacyl Azides

Shivani Sapra; Sunil Kumar Singh; Brajendra K. Singh

doi:10.1039/d6ob00532b

January 1, 2026Organic & Biomolecular Chemistry

Imine-Directed Ru(II)-Catalyzed ortho-C(sp²)–H Amidation of 3-Arylquinoxalin-2(1H)-ones via Nitrene Transfer from Acyl/Heteroacyl Azides

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Key Points

This research aims to explore a new method for forming C-N bonds in specific quinoxaline compounds using Ru(II) catalysis.
Utilized imine-directed Ru(II) catalysis to facilitate ortho C-N bond formation.
Employed acyl and heteroacyl azides as nitrene precursors.
Regioselectivity achieved in the amidation reactions.
Successfully generated C-N bonds in 3-arylquinoxalin-2(1H)-ones with N₂ as the sole byproduct.
Showed effective regioselectivity with a variety of azide precursors.

Implication

Demonstrates regioselective C-N bond formation in quinoxalines, suggesting efficient synthetic pathways.

Abstract

Imine-directed Ru(II)-catalyzed C(sp²)-H amidation enables regioselective ortho C-N bond formation in 3-arylquinoxalin-2(1H)-ones using aromatic acyl azides and heteroaryl acyl azides as nitrene precursors, with N₂ as the sole byproduct of...

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Cite This Study

Sapra et al. (2026) studied this question.

synapsesocial.com/papers/6a12969048a0ea16656737c9 https://doi.org/10.1039/d6ob00532b

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Imine-Directed Ru(II)-Catalyzed ortho-C(sp²)–H Amidation of 3-Arylquinoxalin-2(1H)-ones via Nitrene Transfer from Acyl/Heteroacyl Azides

Key Points

Implication

Abstract

Discussion

Cite This Study

Imine-Directed Ru(II)-Catalyzed ortho-C(sp²)–H Amidation of 3-Arylquinoxalin-2(1H)-ones via Nitrene Transfer from Acyl/Heteroacyl Azides

Key Points

Implication

Abstract

Discussion

Cite This Study

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