Ru(II)-Catalyzed Site-Selective N-Directed C(sp²)–H Alkylation of Quinoxalinones with Maleimide

Monika Monika; Prashant Kumar; Brajendra K. Singh

doi:10.1039/d5ob01524c

January 1, 2025Organic & Biomolecular Chemistry

Ru(II)-Catalyzed Site-Selective N-Directed C(sp²)–H Alkylation of Quinoxalinones with Maleimide

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Key Points

The study demonstrates regioselective alkylation of quinoxalinones with maleimide.
Ruthenium(II) catalyst effective for ortho-C-H alkylation with broad substrate scope.
Catalytic system features [Ru(p-cymene)Cl₂]₂ and AgSbF₆ for optimized performance.
This method may enable more efficient synthesis of complex molecules from simple precursors.

Implication

The ruthenium(II) catalyst demonstrates regioselective alkylation in quinoxalinones, indicating effective use of maleimides.

Abstract

An efficient and highly regioselective ruthenium(II)-catalyzed ortho ‑C-H alkylation of N ‑alkyl‑3‑phenylquinoxalin‑2(1 H )-ones with a broad array of N‑alkyl maleimides is described. Systematic optimization identified [Ru( p ‑cymene)Cl₂]₂/AgSbF₆/AcOH/Cu(OAc)₂·H₂O as an effective catalytic system, operating in...

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Cite This Study

Monika et al. (2025) studied this question.

synapsesocial.com/papers/690fdce2f60c54d04ea38386 https://doi.org/10.1039/d5ob01524c

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Ru(II)-Catalyzed Site-Selective N-Directed C(sp²)–H Alkylation of Quinoxalinones with Maleimide

Key Points

Implication

Abstract

Discussion

Cite This Study

Ru(II)-Catalyzed Site-Selective N-Directed C(sp²)–H Alkylation of Quinoxalinones with Maleimide

Key Points

Implication

Abstract

Discussion

Cite This Study

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