A Ru(II) catalyst improves site-selective C5 functionalization in quinolinones, suggesting compatibility with various functional groups.
A Ru(II)-catalyzed inherent weakly coordinating oxo-group-directed site-selective C5 functionalization of 2-arylquinolin-4(1H)-ones using various coupling partners like allyl alcohols, acrylates, styrenes, maleimides, and acrylamide has been described. The developed method allowed the synthesis of C5-substituted 2-arylquinolin-4(1H)-ones in good to excellent yields. The protocol is compatible with a broad range of functional groups and can be used on the gram scale. In addition, based on the control experiments, a plausible reaction mechanism has been proposed for this transformation.
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Jangir et al. (2025) studied this question.
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