Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism

Jingru Li; Peng Gao; Richard Yi-Tsun Kao; Hongyan Li; Hongzhe Sun

doi:10.1039/d6md00204h

January 1, 2026RSC Medicinal Chemistry

Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism

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Key Points

The research investigates how bismuth can enhance antibiotic effectiveness against biofilm-forming Burkholderia cepacia.
Utilized bismuth as an adjuvant in combination with antibiotics.
Assessed biofilm formation in Burkholderia cepacia cultures.
Measuring antibiotic penetration in the presence of biofilms.
Bismuth significantly reduced biofilm biomass (p<0.01).
Enhanced antibiotic efficacy against B. cepacia in biofilm conditions (p<0.05).
Dual mechanism identified involving biofilm disruption and improved drug delivery.

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Implication

Evaluates bismuth’s ability to reduce biofilm formation in Burkholderia cepacia, suggesting a novel treatment approach.

Abstract

Burkholderia cepacia (B. cepacia) exhibits intrinsic resistance to many conventional antibiotics. A key factor contributing to this resistance is its ability to form biofilms, which hinder antibiotic penetration and make...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80730307b785094326a4 https://doi.org/10.1039/d6md00204h

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Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism

Key Points

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Implication

Abstract

Discussion

Cite This Study

Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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