Statistical data and mortality rates for prostate cancer from 1999 to 2021 in the population of United States-Mexico border areas: Insights from CDC WONDER.

e17106 Background: Prostate cancer is a leading cause of cancer-related mortality among U.S. men. Thisstudy analyzes prostate cancer mortality data from 1999 to 2021 in populations livingalong the United States–Mexico border. Methods: This cohort study used mortality data from CDC WONDER and U.S. Cancer Statistics.Age-adjusted mortality rates (per 100,000) were analyzed by race/ethnicity, region, andurbanization, with trends assessed using Joinpoint regression to estimate AAPC and95% CIs. Results: A total of 924,528 deaths were identified in the United States and Mexico border from1999 to 2021. Overall, AAMR declined significantly during the study period (AAPC:−2.13; 95% CI, −1.82 to −2.45). Males exhibited higher AAMRs throughout and experienced a marked decline from 1999 to 2014 (APC: −3.51; 95% CI, −2.72 to −3.90), followed by an increase from 2018 to 2020 (APC: 2.64; 95% CI, 0.12 to 4.29). By raceand ethnicity, non-Hispanic Black individuals reported the highest AAMRs, while Asianor Pacific Islanders had the lowest rates. AAMRs across census regions were highest inthe West, whereas the Northeast showed the lowest, with a persistent decline (APC,−2.97; 95% CI, −3.27 to −2.68). Non-metropolitan areas exhibited higher AAMRs with alater upward trend after 2014 (APC, 0.79; 95% CI, −0.26 to 1.85) compared withmetropolitan areas. Conclusions: Prostate cancer mortality declined overall from 1999 to 2021; however, recent increasesand persistent racial and regional disparities—particularly in U.S.–Mexico border andnon-metropolitan populations—highlight the need for targeted public healthinterventions.