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May 30, 2026Wiley Interdisciplinary Reviews - RNA

Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix

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Authors

PCPeiyuan ChaiRFRyan A. Flynn

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Overview

Review illustrates how RNA biology extends to the extracellular matrix, indicating implications for cellular interactions.

Key Points

  • This work aims to expand understanding of RNA biology beyond the cytosol and nucleus by exploring its roles in the extracellular matrix.
  • Review of cell surface ribonucleoproteins and glycoRNA interactions with heparan sulfate in the extracellular matrix.
  • Identification of VEGF-A as a noncanonical RNA-binding protein.
  • Analysis of common features between RNA-binding and heparan sulfate-binding domains.
  • VEGF-A is identified as a new cell surface RNA-binding protein.
  • Heparan sulfate regulates spatiotemporal dynamics of cell surface ribonucleoproteins.
  • The interaction between cell surface RNA and VEGF-A suggests new roles for RNA in the extracellular matrix.

Cite This Study

Chai et al. (2026) studied this question.

synapsesocial.com/papers/6a1a816c0307b785094334a1https://doi.org/10.1002/wrna.70048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling2024 · 11 citations
  2. 2Cell-Surface RNA Associates with Heparan Sulfate and RNA-Binding Proteins to Modulate Receptor-Ligand Interactions2024
  3. 3csRNA and heparan sulfate : cell surface ribonucleoproteins regulate HS-mediated signaling2026
  4. 4Potential Function of Glycosylated <scp>RNA</scp> in Diseases2025 · 5 citations
  5. 5Beyond the genome: GlycoRNAs as a nexus of glycobiology and RNA biology2026