Why the study?
Trends in deaths with breast cancer as the underlying cause and cardiometabolic disorders as contributing causes remain poorly characterized, particularly across demographic and geographic subgroups.
Population
167,620 deaths among U.S. women aged ≥45 years
Comparison
Trends stratified by race, U.S. census region, and urbanization
Design
Retrospective mortality data analysis using joinpoint regression
Key result
Mortality for breast cancer with cardiometabolic contributions among U.S. women ≥45 years increased sharply from 2018–2021 (APC +6.88%, p<0.01), disproportionately affecting Black women.
Authors
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Rising cardiometabolic-linked breast cancer mortality, especially among Black women, warrants vigilance; leaves open whether targeted interventions can reduce disparities.
Observational (n=167,620)
Yes
Effect estimate: APC +6.88%
p-value: p=<0.01
Breast cancer mortality with contributing cardiometabolic disorders is rising among U.S. women aged ≥45, with significant racial and geographic disparities highlighting the need for targeted cardio-oncology interventions.
Jamshed et al. (2026) conducted an observational in Breast cancer with contributing cardiometabolic disorders (n=167,620). Mortality for breast cancer with cardiometabolic contributions among U.S. women ≥45 years increased sharply from 2018–2021 (APC +6.88%, p<0.01), disproportionately affecting Black women.