Why the study?
The study evaluated the associations between midlife weight-change patterns and the incidence of CVD across physical activity levels.
Does long-term weight-change trajectory (such as gradual weight loss) affect the incidence of cardiovascular disease in CVD-free midlife adults, and is this modified by physical activity?
Does long-term weight-change trajectory (such as gradual weight loss) affect the incidence of cardiovascular disease in CVD-free midlife adults, and is this modified by physical activity?
Answers are grounded in this paper and cite their sources.
Gradual weight loss in midlife is associated with an increased risk of cardiovascular disease, particularly among individuals with low baseline physical activity levels.
Using data from the Korean Genome and Epidemiology Study, we identified weight-change patterns during midlife using a group-based trajectory model, and evaluated their associations with the incidence of cardiovascular disease (CVD). At baseline, there were 8774 CVD-free participants. Group-based modeling was used to analyze patterns of weight change over about 16 years. Using multiple model, we evaluated the association between weight-change patterns and CVD risk. During the follow-up period, 741 new CVD cases were identified. The weight-change patterns were characterized as ‘gradual weight gain’, ‘stable weight’, ‘slight weight loss’, and ‘gradual weight loss’. The association between weight-change patterns and CVD risk differed depending on the level of physical activity (PA) at baseline ( p interaction < 0.05). Compared with the stable-weight group, the risk of all CVD (HR 2.5, 95% CI 1.5–4.3) and non-fatal CVD (HR 2.8, 95% CI 1.6–4.9) among the gradual-weight-loss group was apparent in the lowest PA quartile. In addition, on average, a decrease in skeletal-muscle-mass (SMM) levels was observed during the follow-up period, but the decrease in SMM in the gradual-weight-loss group was greater than in the gradual-weight-gain group. Our findings show that gradual weight loss was associated with CVD risk, which was dependent on PA levels.
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Lee et al. (2022) studied this question.
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