Key result
Losing weight to transition from obese to nonobese over 5 years significantly slowed the increase in predicted 10-year cardiovascular disease risk (5.9% to 6.9%) compared to remaining stably obese.
Why the study?
The study investigated the influence of weight change on concurrent changes in predicted cardiovascular disease risk and individual CVD risk factors over time.
Does weight loss in obese individuals or weight gain in nonobese individuals affect predicted cardiovascular disease risk and risk factors in community residents?
Cohort (n=2,140)
No
Does weight loss in obese individuals or weight gain in nonobese individuals affect predicted cardiovascular disease risk and risk factors in community residents?
p-value: p=<0.01
Losing weight in obese individuals and avoiding weight gain in nonobese individuals is associated with favorable changes in predicted future CVD risk and individual risk factors.
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May support weight loss counseling in obesity to slow CVD risk progression; hypothesis-generating pending randomized outcome trials.
Honda et al. (2021) conducted a cohort in Community-dwellers (n=2,140). Weight loss (obese to nonobese) vs. Stable obese was evaluated on Change in model-predicted 10-year cumulative risk for cardiovascular disease (p=<0.01). Losing weight to transition from obese to nonobese over 5 years significantly slowed the increase in predicted 10-year cardiovascular disease risk (5.9% to 6.9%) compared to remaining stably obese.
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