Body Weight, Weight change and the Risk of Cardiovascular Disease in Patients with Hypertension: A Primary-care Cohort Study

Background/objectives: Obesity and cardiovascular disease (CVD) often co-occur. However, the effects of excessive body weight and weight change on CVD in patients with hypertension is not clearly established. We examined the associations of BMI, weight change and the risk of CVD in patients with hypertension. Subjects/methods: Our Data were drawn from the medical records of primary-care institutions in China. A total of 25 810 patients with valid weight measurements attending primary healthcare centers were included. Body weight were grouped in BMI categories of underweight (<18.5kg/m 2 ), normal weight (18.5–22.9 kg/m 2 ), overweight (23.0–24.9 kg/m 2 ) and obesity (≥25.0 kg/m 2 ). Weight change over 12 months was divided into: gain >4%, gain 1%–4%, stable (–1%–1%), loss 1%–4%, and loss ≥4%. Cox regression analyses were used to estimate hazard ratio (HR) and 95% confidence interval (95% CI) between BMI, weight change and the risk of CVD. Result: After multivariable adjustment, patients with obesity were related to higher risks of CVD (HR=1.46, 95% CI: 1.22–1.75). Higher risks were seen in participants with loss ≥4%, gain 1–4% and gain >4% of body weight compared to stable weight (loss ≥4%: HR=1.26, 95% CI: 1.02–1.55; gain 1–4%: HR=1.31, 95% CI: 1.04–1.64; gain >4%: HR=1.34, 95% CI: 1.08–1.66). Conclusion: Obesity and weight change of loss ≥4%, gain 1–4% and gain >4% were related to higher risks of CVD. Close monitoring and appropriate interventions aimed at achieving an optimal weight are needed to prevent adverse outcomes for patients with hypertension.