September 9, 2002Archives of Internal Medicine
Overweight and Obesity as Determinants of Cardiovascular Risk
Key result
Obesity increased the risk of new cardiovascular disease compared to normal weight in men (RR 1.46; 95% CI 1.20-1.77) and women (RR 1.64; 95% CI 1.37-1.98).
Why the study?
Does overweight and obesity increase the risk of new cardiovascular disease in adults aged 35 to 75 years?
Population
Framingham Heart Study participants aged 35 to 75 years
Comparison
Overweight and obese status vs Normal-weight persons (BMI 18.5-24.9)
Design
Cohort
Follow-up
up to 44 years
Authors
Discussion
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Implication
Obesity was associated with higher CVD risk; extends observational data but leaves causal effects of weight loss open for trials.
Study Design
Type
Cohort
Structured PICO
Does overweight and obesity increase the risk of new cardiovascular disease in adults aged 35 to 75 years?
P
Population
Framingham Heart Study participants aged 35 to 75 years, followed for up to 44 years to assess the impact of BMI categories on cardiovascular disease.
E
Exposure
Overweight (BMI 25.0-29.9) and obese (BMI ≥30) status
C
Comparator
Normal-weight persons (BMI 18.5-24.9)
O
Outcome
New cardiovascular disease, which included angina pectoris, myocardial infarction, coronary heart disease, or strokecomposite
Main Result
Relative Risk: 1.46 (95% CI 1.2–1.77)
Overweight and obesity are associated with a significantly increased long-term risk of developing hypertension and cardiovascular disease.
Cite This Study
Wilson et al. (2002) conducted a cohort in Cardiovascular risk. Overweight and obesity vs. Normal-weight persons (BMI 18.5-24.9) was evaluated on New cardiovascular disease (angina pectoris, myocardial infarction, coronary heart disease, or stroke) (RR 1.46, 95% CI 1.20-1.77). Obesity increased the risk of new cardiovascular disease compared to normal weight in men (RR 1.46; 95% CI 1.20-1.77) and women (RR 1.64; 95% CI 1.37-1.98).