Through positive and negative selection, the thymus allows a small fraction of immature CD4+8+ double positive thymocytes to differentiate into mature CD4+8− or CD4−8+ single positive cells; these cells are released into the periphery to establish the mature T cell pool. Positive selection
No takes yet. Share an insight, caveat, or question.
Surh et al. (2000) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: