Population
Rat ventricular myocytes (and atrial cells)
Comparison
Detubulation vs Control (non-detubulated) myocytes
Design
Preclinical
Authors
Loading...
NCX concentration in t-tubules shapes Ca2+ release in rat myocytes; leaves open translation to human disease models with t-tubule remodeling.
Na+-Ca2+ exchange function is concentrated in the t-tubules of rat ventricular myocytes, playing an important role in uniform intracellular Ca2+ release during excitation-contraction coupling.
Yang et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: