Why the study?
Malignant hypertension is an extremely severe form of hypertension with target organ impairment, and resveratrol has been proposed as an effective agent in preventing cardiovascular diseases.
Does chronic resveratrol administration reduce blood pressure and improve cardiac structure in spontaneously and malignantly hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs) and malignantly hypertensive rats (MHRs)
Comparison
Chronic resveratrol administration vs untreated control
Design
Animal experimental study
Authors
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Resveratrol's benefits in hypertensive rats should not change clinical practice; hypothesis-generating for human trials.
Does chronic resveratrol administration reduce blood pressure and improve cardiac structure in spontaneously and malignantly hypertensive rats?
In a rat model, resveratrol prevents hypertrophic and apoptotic consequences of high blood pressure, with pronounced protective effects in malignant hypertension.
Grujić-Milanović et al. (2021) studied this question.
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