Metabolizer phenotype prediction in different Peruvian ethnic groups through CYP2C9 polymorphisms

Objectives The CYP2C9 gene have three common alleles, CYP2C9*1 , CYP2C9*2 and CYP2C9*3 , associated with different homozygous ( *1/*1, *2/*2 and *3/*3 ) and heterozygous ( *1/*2 and *1/*3 ) genotypes, which in turn are related to extensive ( g EM), intermediate ( g IM) and poor ( g PM) metabolizers. Likewise, the inter-ethnic variability was intimately associated with different drug metabolism. Therefore, the aim of the present study was predict the metabolizer phenotypes in different Peruvian ethnic groups from lowland (<2,500 m) and highland (>2,500 m). Methods TaqMan genotyping assays were performed in a group of 174 healthy unrelated Peruvian individuals. Results In this study, the allelic comparison between the three eco-regions showed that the CYP2C9*1 was the most common in Andean (96.32%); the *2 was the most frequent in Coast (7.45%, p<0.05). Regarding the *3 was the most common in Amazonian (6.25%, p<0.05). In a corroborative manner, the g EM was the most common in Andean (94.74%), the g IM in Coast (17.02%) and g PM in Amazonian (6.25%) populations. Conclusions Our study provides a valuable source of information about to metabolizer phenotype drugs in different Peruvian ethnic groups. In this way, it could be established suitable genetic-dosage medicaments for various common diseases in these heterogenetic populations.