Prognostic capacity of the leuko-glycemic index in cardiac syndrome Y

Objectives Cardiac syndrome Y (CSY) phenomenon is characterized by the gradual opacification of the coronary vasculature at the distal level. The leuko-glycemic index (LGI) is a blood glucose and white blood cell count index. This study investigates the relationship between CSY and the leuko-glycemic index. Methods A case-control, retrospective study was conducted. Consecutively selected individuals with complaints of angina were included in the study. Subjects with normal coronary flow ( n = 132) and coronary slow flow ( n = 136) were classified, after confirmation of coronary angiography results. Results The age ranges were recorded as 57 (48–64) for the NCF group vs. 52 (46–58) for the CSY group, P = .010. The mean hematocrit (Hct), Hemoglobin (Hg), White blood cells (WBC), and LGI were significantly higher in the CSY group than in the normal coronary flow group ( P < .001). Accordingly, CSY was positively correlated with Hct, Hg, and WBC ( P < .001). ROC curve analysis indicated that a cut-off value of ≥9.28 for the LGI predicted CSF with a sensitivity of 78% and a specificity of 78.1% [Area under the curve (AUC): 0.626 and 95% CI: 0.559–0.693]. Conclusions In this study, we show for the first time that elevated LGI levels can independently predict CSF formation in the subclinical process.