Why the study?
Does endothelial impairment affect flow-dependent arteriolar dilation and wall shear stress in rat skeletal muscle microcirculation?
Population
Pentobarbital-anesthetized rats (cremaster muscle arterioles, n=21)
Comparison
Increase in blood flow velocity and impairment… vs Intact endothelium in control conditions
Design
Preclinical
Authors
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Endothelial impairment abolishes flow-mediated dilation despite elevated shear in rat arterioles; leaves open relevance to human microvascular disease.
Does endothelial impairment affect flow-dependent arteriolar dilation and wall shear stress in rat skeletal muscle microcirculation?
Koller et al. (1991) studied this question.
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