Endothelial cell dilatory pathways link flow and wall shear stress in an intact arteriolar network

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Population

Pentobarbital sodium-anesthetized hamsters (n=51)

Comparison

Tissue exposure to 50 microM N… vs Control state

Design

Preclinical

Authors

Discussion

Animal data implicate endothelial dilatory pathways in arteriolar flow-shear coupling; hypothesis-generating and not ready for clinical translation.

Population

Pentobarbital sodium-anesthetized hamsters (n=51)

Intervention

Tissue exposure to 50 microM N omega-nitro-L-arginine + 50 microM indomethacin (L-NNA + Indo), 5% O2, or 10(-9) M norepinephrine (NE)

Comparator

Control state

Outcome

Cell flow, wall shear stress (T omega), diameter, and bifurcation angle in sequential branches of a transverse arteriolesurrogate

Endothelial cell dilatory pathways are essential for coupling flow and wall shear stress in intact arteriolar networks.

Frame et al. (1996) studied this question.

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Animal data implicate endothelial dilatory pathways in arteriolar flow-shear coupling; hypothesis-generating and not ready for clinical translation.