May 1, 2002Journal of Applied Physiology

Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouch

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Population

Hamsters (n = 34, anesthetized with pentobarbital sodium 70 mg/kg)

Comparison

Suffused adenosine or sodium nitroprusside 10 to… vs Baseline conditions

Design

Preclinical

Authors

RFRandall J. FoxUniversity of Rochester MFMary D. FrameStony Brook University

Discussion

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Implication

Preclinical heterogeneous responses warrant no practice change; hypothesis-generating for microvascular shear regulation in humans.

Structured PICO

Population

Hamsters (n = 34, anesthetized with pentobarbital sodium 70 mg/kg)

Intervention

Suffused adenosine or sodium nitroprusside (SNP) 10(-9) to 10(-5) M

Comparator

Baseline conditions

Outcome

Arteriolar diameter, red blood cell flux, and velocitysurrogate

This preclinical study demonstrates that arteriolar networks exhibit heterogeneous, location-dependent responses to vasodilators like adenosine and SNP, highlighting complex local regulation of flow and shear stress.

Cite This Study

Fox et al. (2002) studied this question.

synapsesocial.com/papers/6a83faef902d1005cc4a1012 https://doi.org/10.1152/japplphysiol.00984.2001

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Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouch

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouch

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider