Key result
Epinephrine infusion produced a 25% increase in myocardial perfusion without beta-blockade, but a 20% decrease via nonuniform microvascular constriction in the presence of beta-blockade.
Why the study?
Does epinephrine have nonuniform effects on coronary microvascular diameters in the presence or absence of beta-adrenergic blockade in an open-chest cat model?
Population
Anesthetized, open-chest cat preparations
Comparison
Epinephrine infusion in the absence and presence… vs Baseline conditions prior to epinephrine infusion
Design
Preclinical
Authors
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May caution epinephrine use under beta-blockade in coronary models; leaves open translation to human microvascular physiology.
Does epinephrine have nonuniform effects on coronary microvascular diameters in the presence or absence of beta-adrenergic blockade in an open-chest cat model?
Epinephrine produces uniform coronary vasodilation and increased perfusion normally, but causes nonuniform microvascular constriction and decreased perfusion when beta-adrenergic receptors are blocked.
Chilian et al. (1987) studied this question. Epinephrine vs. Absence vs presence of β-adrenergic blockade (propranolol 1 mg/kg) was evaluated on Myocardial perfusion and coronary microvascular diameters. Epinephrine infusion produced a 25% increase in myocardial perfusion without beta-blockade, but a 20% decrease via nonuniform microvascular constriction in the presence of beta-blockade.
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