Why the study?
Does Bendavia adjunct to PTRS improve cardiac function and reduce myocardial injury in a swine model of renovascular hypertension?
Population
Swine model of renovascular hypertension (unilateral renal artery stenosis for 6 weeks)
Comparison
Bendavia adjunct to percutaneous transluminal… vs Vehicle adjunct to PTRS
Design
Preclinical
Follow-up
4 weeks
Authors
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These swine data support human trials of Bendavia in renovascular hypertension; leaves open clinical use with PTRS.
Does Bendavia adjunct to PTRS improve cardiac function and reduce myocardial injury in a swine model of renovascular hypertension?
In a swine model of renovascular hypertension, adjunct mitochondrial-targeted peptide therapy (Bendavia) during renal revascularization improved diastolic function and reversed myocardial tissue damage.
Eirin et al. (2013) studied this question.