June 1, 2016Journal of the American Heart AssociationOpen Access

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

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Why the study?

Does mitochondrial-targeted peptide Bendavia improve cardiac remodeling and function in a swine model of renovascular hypertension?

Population

Swine model of hypercholesterolemic renovascular hypertension and controls, as well as rat cardiomyocytes…

Comparison

Mitochondrial-targeted peptide Bendavia for 4… vs Vehicle.

Design

Preclinical

Follow-up

4 weeks

Authors

AEAlfonso EirinVascular / Pulmonary Vascular BEBehzad EbrahimiUniversity of Southern California SKSoon Hyo KwonSoonchunhyang University Hospital Seoul

Discussion

Member takes

Implication

Animal data support mitochondrial protection as a research target in hypertensive heart disease; human trials needed before clinical consideration.

Structured PICO

Does mitochondrial-targeted peptide Bendavia improve cardiac remodeling and function in a swine model of renovascular hypertension?

Population

Swine model of hypercholesterolemic renovascular hypertension (HC-RVH) and controls (n=28 total, 14 each), as well as rat cardiomyocytes treated with tert-butyl hydroperoxide (tBHP).

Intervention

Mitochondrial-targeted peptide (MTP) Bendavia (0.1 mg/kg subcutaneously, 5 days/week) for 4 weeks.

Comparator

Vehicle.

Outcome

Cardiac function (assessed by multidetector-computed tomography), oxygenation (by BOLD MRI), cardiolipin content, mitochondrial biogenesis, sarcoplasmic-reticulum calcium cycling, myocardial tissue injury, and coronary endothelial function.surrogate

Mitochondrial-targeted therapy with Bendavia attenuates myocardial hypertrophy and improves LV relaxation in a swine model of renovascular hypertension, suggesting mitochondrial injury contributes to hypertensive cardiomyopathy.

Cite This Study

Eirin et al. (2016) studied this question.

synapsesocial.com/papers/6a7d2990469c795fc42791b7 https://doi.org/10.1161/jaha.115.003118

Topics

Cardiomyopathy

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Implication

Animal data support mitochondrial protection as a research target in hypertensive heart disease; human trials needed before clinical consideration.

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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