December 2, 2020American Journal of HypertensionOpen Access

Renovascular Hypertension Induces Myocardial Mitochondrial Damage, Contributing to Cardiac Injury and Dysfunction in Pigs With Metabolic Syndrome

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Why the study?

Coexisting renovascular hypertension and metabolic syndrome increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown.

Population

Pigs (n = 6 each group)

Comparison

Diet-induced MetS with or without RVH vs Lean controls

Design

Preclinical animal study

Follow-up

16 weeks

Authors

ANArash Aghajani NargesiGeneral Cardiology MFMohamed C FarahMayo Clinic XZXiang-Yang ZhuMayo Clinic

Discussion

Member takes

Implication

May worsen diastolic dysfunction in MetS with RVH via impaired mitophagy; leaves open whether targeting mitophagy benefits patients.

Structured PICO

Population

Pigs with diet-induced metabolic syndrome (MetS) with or without renovascular hypertension (RVH via unilateral renal artery stenosis), and Lean controls (n = 6 each group)

Intervention

Diet-induced metabolic syndrome combined with renovascular hypertension (unilateral renal artery stenosis) for 16 weeks

Comparator

Lean controls, Lean pigs with RVH, and pigs with MetS alone

Outcome

Systolic and diastolic cardiac function, cardiac mitochondrial morphology, and myocardial functionsurrogate

In a porcine model, the superimposition of metabolic syndrome on renovascular hypertension exacerbates cardiac remodeling and diastolic dysfunction due to impaired mitophagy.

Cite This Study

Nargesi et al. (2020) studied this question.

synapsesocial.com/papers/6a7d78bf4bbb2340c9d5a2a3 https://doi.org/10.1093/ajh/hpaa202

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Renovascular Hypertension Induces Myocardial Mitochondrial Damage, Contributing to Cardiac Injury and Dysfunction in Pigs With Metabolic Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renovascular Hypertension Induces Myocardial Mitochondrial Damage, Contributing to Cardiac Injury and Dysfunction in Pigs With Metabolic Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider