Why the study?
Metabolic dysregulation in the pressure-loaded right ventricle may vary across experimental models and disease severity, complicating translation of metabolic therapies to human disease.
What are the metabolic changes in the pressure-loaded right ventricle across different experimental models and human disease?
What are the metabolic changes in the pressure-loaded right ventricle across different experimental models and human disease?
The pressure-loaded right ventricle exhibits a consistent increase in glucose uptake and glycolysis with a downregulation of beta-oxidation, though oxidative metabolism changes are model-specific.
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Supports metabolic targeting in RV pressure overload; extends single-model findings to meta-analytic confirmation across experiments and human disease.
Koop et al. (2019) studied this question.
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