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March 2, 2022ESC Heart FailureOpen Access

Evaluation of Diastole by Echocardiography for Detecting Early Cardiac Dysfunction: An Outcome Study

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Why the study?

Timely detection of subclinical left ventricular diastolic dysfunction is important for risk stratification of asymptomatic subjects, but the prevalence and prognostic significance using different grading approaches needed evaluation.

Does grading LVDDF using population-derived, age-specific criteria improve prediction of adverse cardiac events in community-dwelling participants compared to the 2016 ASE/EACVI recommendations?

Population

1407 community-dwelling participants

Comparison

2016 ASE/EACVI recommendations vs population-derived, age-specific criteria

Design

Prospective cohort study

Follow-up

8.4 years

Key result

Classifying left ventricular diastolic dysfunction using population-derived, age-specific criteria significantly predicted adverse cardiac events (HR 1.28; P=0.0045), unlike the 2016 recommendations.

Authors

TKTatiana KuznetsovaNCNicholas CauwenberghsFSFrantišek Sabovčik

Discussion

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Member takes

Overview

May enhance risk stratification versus 2016 criteria in community cohorts; hypothesis-generating, requiring prospective validation before practice change.

Study Design

Type

Cohort (n=1,407)

Structured PICO

Does grading LVDDF using population-derived, age-specific criteria improve prediction of adverse cardiac events in community-dwelling participants compared to the 2016 ASE/EACVI recommendations?

P
Population
1407 community-dwelling participants (mean age, 51.2 years; 51.1% women; 53.5% with cardiovascular risk factors).
I
Intervention
Grading of left ventricular diastolic dysfunction (LVDDF) using population-derived, age-specific criteria based on echocardiography and Doppler imaging
C
Comparator
Grading of LVDDF using the 2016 ASE/EACVI recommendations
O
Outcome
Adverse cardiac events over 8.4 years follow-upcomposite

Main Result

Effect estimate: HR 1.28

p-value: p=0.0045

Using age- and population-derived thresholds for grading left ventricular diastolic dysfunction improves risk stratification and outcome prediction compared to the standard 2016 ASE/EACVI recommendations.

Cite This Study

Kuznetsova et al. (2022) conducted a cohort in subclinical left ventricular diastolic dysfunction (LVDDF) (n=1,407). Population-derived, age-specific criteria for LVDDF grading vs. 2016 ASE/EACVI recommendations was evaluated on adverse cardiac events (HR 1.28, p=0.0045). Classifying left ventricular diastolic dysfunction using population-derived, age-specific criteria significantly predicted adverse cardiac events (HR 1.28; P=0.0045), unlike the 2016 recommendations.

synapsesocial.com/papers/6a1ab02b9fa30811a0b8fafbhttps://doi.org/10.1002/ehf2.13863
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