What is the clinical evidence from this study?

Study design: Observational. Population: Breast, prostate, or colorectal cancer (n=55). Intervention: Adjuvant chemotherapy vs. Adjuvant endocrine therapy. Primary outcome: Percentage change in maximal oxygen uptake (VO2max) from baseline to six months (Mean difference -10%, 95% CI -19.000 to -1.131, p=0.028).

What does this research mean for the field?

Adjuvant chemotherapy is associated with a 10% decline in maximal oxygen uptake at six months compared to endocrine therapy, whereas higher baseline physical activity is associated with maintenance of maximal oxygen uptake. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 3, 2020BMC Sports Science Medicine and RehabilitationOpen Access

The Phys-Can observational study: adjuvant chemotherapy is associated with a reduction whereas physical activity level before start of treatment is associated with maintenance of maximal oxygen uptake in patients with cancer

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Key result

Adjuvant chemotherapy was associated with a 10% decline in maximal oxygen uptake at six months compared to endocrine therapy, whereas higher baseline physical activity was associated with maintenance of maximal oxygen uptake.

Why the study?

There was limited knowledge regarding the effect of different types of adjuvant cancer treatment on cardiorespiratory fitness in cancer populations beyond breast cancer.

Does adjuvant chemotherapy reduce VO2max compared to endocrine therapy, and does baseline physical activity improve VO2max maintenance in patients with cancer?

Population

85 patients scheduled for adjuvant treatment for breast, prostate, or colorectal cancer

Comparison

Adjuvant treatment type, physical activity level, and clinical correlates

Design

Prospective observational study

Follow-up

six months

Authors

TWTor Helge WiestadHaukeland University Hospital TRTruls RaastadNorwegian School of Sport Sciences KNKarin NordinUppsala University

Discussion

Member takes

Implication

May warrant fitness monitoring during chemotherapy; hypothesis-generating for activity maintenance, needs RCTs to confirm.

Study Design

Type

Observational (n=55)

Multicenter

Yes

Structured PICO

Does adjuvant chemotherapy reduce VO2max compared to endocrine therapy, and does baseline physical activity improve VO2max maintenance in patients with cancer?

Population

85 patients aged ≥18 recently diagnosed with breast, prostate, or colorectal cancer scheduled for adjuvant cancer treatment, mean age 58.8, 80.8% female, based in Sweden.

Intervention

Adjuvant chemotherapy

Comparator

Adjuvant endocrine treatment

Outcome

Changes in maximal oxygen uptake (VO2max) during a maximal incremental exercise test on a treadmill from baseline to six months latersurrogate

Main Result

Effect estimate: Mean difference -10% (95% CI -19.000 to -1.131)

p-value: p=0.028

Adjuvant chemotherapy is associated with a significant decline in cardiorespiratory fitness in cancer patients, but higher baseline physical activity levels may help maintain maximal oxygen uptake during treatment.

Limitations

Less than 50% of the eligible patients completed the study.
There was a larger proportion of women and patients with breast cancer among the included patients, limiting generalizability to colorectal or prostate cancer.
The sample consisted of patients sufficiently fit to participate, who might be more active than the average patient group.

Cite This Study

Wiestad et al. (2020) conducted an observational in Breast, prostate, or colorectal cancer (n=55). Adjuvant chemotherapy vs. Adjuvant endocrine therapy was evaluated on Percentage change in maximal oxygen uptake (VO2max) from baseline to six months (Mean difference -10%, 95% CI -19.000 to -1.131, p=0.028). Adjuvant chemotherapy was associated with a 10% decline in maximal oxygen uptake at six months compared to endocrine therapy, whereas higher baseline physical activity was associated with maintenance of maximal oxygen uptake.

synapsesocial.com/papers/6a1ab05049c6765e3885cd75 https://doi.org/10.1186/s13102-020-00205-9

Topics

Cardio-oncology

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September 3, 2020BMC Sports Science Medicine and RehabilitationOpen Access

The Phys-Can observational study: adjuvant chemotherapy is associated with a reduction whereas physical activity level before start of treatment is associated with maintenance of maximal oxygen uptake in patients with cancer

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

There was limited knowledge regarding the effect of different types of adjuvant cancer treatment on cardiorespiratory fitness in cancer populations beyond breast cancer.

Does adjuvant chemotherapy reduce VO2max compared to endocrine therapy, and does baseline physical activity improve VO2max maintenance in patients with cancer?

Population

85 patients scheduled for adjuvant treatment for breast, prostate, or colorectal cancer

Comparison

Adjuvant treatment type, physical activity level, and clinical correlates

Design

Prospective observational study

Follow-up

six months

Authors

TWTor Helge WiestadHaukeland University Hospital TRTruls RaastadNorwegian School of Sport Sciences KNKarin NordinUppsala University

Discussion

Member takes

Implication

May warrant fitness monitoring during chemotherapy; hypothesis-generating for activity maintenance, needs RCTs to confirm.

Study Design

Type

Observational (n=55)

Multicenter

Yes

Structured PICO

Does adjuvant chemotherapy reduce VO2max compared to endocrine therapy, and does baseline physical activity improve VO2max maintenance in patients with cancer?

Population

85 patients aged ≥18 recently diagnosed with breast, prostate, or colorectal cancer scheduled for adjuvant cancer treatment, mean age 58.8, 80.8% female, based in Sweden.

Intervention

Adjuvant chemotherapy

Comparator

Adjuvant endocrine treatment

Outcome

Changes in maximal oxygen uptake (VO2max) during a maximal incremental exercise test on a treadmill from baseline to six months latersurrogate

Main Result

Effect estimate: Mean difference -10% (95% CI -19.000 to -1.131)

p-value: p=0.028

Limitations

Less than 50% of the eligible patients completed the study.
There was a larger proportion of women and patients with breast cancer among the included patients, limiting generalizability to colorectal or prostate cancer.
The sample consisted of patients sufficiently fit to participate, who might be more active than the average patient group.

Cite This Study

synapsesocial.com/papers/6a1ab05049c6765e3885cd75 https://doi.org/10.1186/s13102-020-00205-9

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Cardio-oncology

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