Why the study?
What is the incidence of cardiac adverse events associated with targeted therapies for breast cancer?
What is the incidence of cardiac adverse events associated with targeted therapies for breast cancer?
Targeted therapies for breast cancer, such as anti-HER2 and antiangiogenic agents, carry a significant risk of cardiovascular adverse events, highlighting the need for cardio-oncology monitoring.
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Supports cardio-oncology vigilance with targeted breast cancer therapies; leaves open optimal monitoring protocols and risk-reduction trials.
The concept of 'targeted' therapies implies that such drugs only act on cells that specifically express the particular target, therefore giving rise to a low incidence of side effects. However, targeted therapies currently approved for the treatment of breast cancer have demonstrated a relatively high incidence of cardiovascular events. The anti-HER2 agents trastuzumab and lapatinib may cause left ventricular dysfunction or even congestive heart failure. Bevacizumab, an antiangiogenic drug, has been shown to increase the risk of hypertension, cardiovascular dysfunction and thromboembolic events. In addition, several anti-human epidermal growth factor receptor 2 (HER2) and antiangiogenic agents plus their combinations are currently being developed and evaluated for the treatment of breast cancer. In this review, we aim to assess the incidence of cardiac adverse events associated with targeted therapies designed to block HER2 and angiogenic pathways.
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Criscitiello et al. (2012) studied this question.
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