Control of 24-hour blood pressure with SGLT2 inhibitors to prevent cardiovascular disease
Key result
SGLT2 inhibitors provide sustained improvements in 24-hour blood pressure profiles, supporting their role as effective blood pressure-lowering agents in patients with type 2 diabetes and hypertension.
Why the study?
Do SGLT2 inhibitors reduce 24-hour blood pressure and prevent cardiovascular disease in patients with type 2 diabetes mellitus and hypertension?
Design
Review
Authors
Discussion
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Member takes
Implication
Supports 24-hour BP lowering with SGLT2 inhibitors in T2DM hypertension; leaves open dedicated CVD outcome trials.
Structured PICO
Do SGLT2 inhibitors reduce 24-hour blood pressure and prevent cardiovascular disease in patients with type 2 diabetes mellitus and hypertension?
P
Population
Patients with type 2 diabetes mellitus (T2DM) and hypertension (HTN)
I
Intervention
SGLT2 inhibitors (SGLT2i)
O
Outcome
24-hour, daytime, and nocturnal blood pressure reduction and cardiovascular disease preventionsurrogate
SGLT2 inhibitors provide sustained improvements in 24-hour blood pressure profiles, supporting their role in managing poorly controlled hypertension and reducing cardiovascular risk in patients with T2DM.
Cite This Study
Kario et al. (2020) conducted a review in Type 2 Diabetes Mellitus and Hypertension. SGLT2 inhibitors was evaluated. SGLT2 inhibitors provide sustained improvements in 24-hour blood pressure profiles, supporting their role as effective blood pressure-lowering agents in patients with type 2 diabetes and hypertension.