Key result
Echocardiographic parameters of diastolic function physiologically deteriorated with age, with the transmitral E/A ratio decreasing from a mean of 1.65 in subjects under 30 to 0.78 in those over 80.
Why the study?
Data on the effect of age on various echocardiographic parameters of left ventricular diastolic function were limited.
Does age affect echocardiographic parameters of left ventricular diastolic function independently of comorbidities?
Observational (n=999)
No
Does age affect echocardiographic parameters of left ventricular diastolic function independently of comorbidities?
Absolute Event Rate: 0.78% vs 1.65%
p-value: p=<0.001
Echocardiographic parameters of left ventricular diastolic function deteriorate physiologically with age, independent of comorbidities like hypertension or coronary artery disease.
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Pyszko et al. (2018) conducted an observational in Left ventricular diastolic function (n=999). Age (aging) vs. Younger age (<30 years) was evaluated on Transmitral E/A ratio (p=<0.001). Echocardiographic parameters of diastolic function physiologically deteriorated with age, with the transmitral E/A ratio decreasing from a mean of 1.65 in subjects under 30 to 0.78 in those over 80.
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