Key result
Prescription of beta-blockers was associated with a higher likelihood of antihypertensive drug discontinuation within 180 days compared to thiazide diuretics (aOR 1.67, P<0.001).
Why the study?
Are age, gender, and specific antihypertensive drug classes associated with drug discontinuation in Chinese patients?
Population
93,286 adult Chinese patients prescribed an antihypertensive medication between January 2004 and June 2007…
Comparison
Antihypertensive drug classes and demographic… vs Thiazide diuretics, older age groups, female…
Design
Cohort
Follow-up
180 days
Authors
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May warrant closer adherence monitoring with beta-blockers; leaves open causality and generalizability beyond this cohort.
Cohort (n=93,286)
No
Are age, gender, and specific antihypertensive drug classes associated with drug discontinuation in Chinese patients?
Effect estimate: aOR 1.67
p-value: p=<0.001
Younger age, male gender, and beta-blocker use are associated with higher rates of early antihypertensive drug discontinuation in Chinese patients, highlighting the need for targeted adherence monitoring.
Wong et al. (2009) conducted a cohort in Hypertension (n=93,286). Beta-blockers vs. Thiazide diuretics was evaluated on Drug discontinuation within 180 days after the first prescription date (aOR 1.67, p=<0.001). Prescription of beta-blockers was associated with a higher likelihood of antihypertensive drug discontinuation within 180 days compared to thiazide diuretics (aOR 1.67, P<0.001).
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