Key result
AMPD1 CT genotype links to reduced jump height while ACE and HIF1A correlate with greater power.
Why the study?
The study aimed to investigate the influence of selected gene polymorphisms on vertical jump performance and adaptive responses before and after a standard training session in elite basketball and volleyball players compared to a control group.
Do ACE, ACTN3, PPARA, HIF1A, and AMPD1 gene polymorphisms influence vertical jump performance before and after a training session in elite athletes compared to controls?
Observational
Do ACE, ACTN3, PPARA, HIF1A, and AMPD1 gene polymorphisms influence vertical jump performance before and after a training session in elite athletes compared to controls?
p-value: p=<0.05
Specific gene polymorphisms, including AMPD1, ACE, and HIF1A, exert variable influences on vertical jump performance and training adaptation depending on the individual's level of training.
AMPD1 CT genotype was associated with lower jump height in athletes; hypothesis-generating for performance genetics, no practice change yet.
Background/objectives: The study aims to investigate potential differences in vertical jump performance between elite basketball and volleyball players before and after a standard training session, in comparison to a control group from the general population. The analysis focuses on the influence of selected gene polymorphisms that may contribute to variations in the assessed performance parameters. Aims: The aim was to investigate the influence of ACE (rs4646994), ACTN3 (rs1815739), PPARA rs4253778, HIF1A (rs11549465), and AMPD1 (rs17602729) genes polymorphisms on the combined effects of post-activation potentiation (PAP), post-activation performance enhancement (PAPE), and general adaptation syndrome (GAS), as reflected in vertical jump performance, in elite basketball and volleyball players compared to a control group from the general population. Methods: The effects of PAP at the beginning of the training load (acute exercise), and the combined influences of PAPE and GAS following the training load were evaluated using parameters measured by the OptoJump Next® system (Microgate, Bolzano, Italy). Results: A statistically significant (h, p < 0.05) negative effect of the CT genotype of the AMPD1 gene on jump height was observed in the group of athletes. The CT genotype of the AMPD1 gene negatively impacted on PAPE and GAS adaptive responses (ΔP, Δh, p < 0.001) also in the control group. A positive effect on the power during the active phase of the vertical jump was identified for the II genotype of the ACE gene and the Pro/Ser genotype of the HIF1A gene, both exclusively in the control group (ΔP, p < 0.05). Conclusion: Our findings demonstrate that different gene polymorphisms exert variable influences on the combined effects of PAPE and GAS, as reflected in vertical jump parameters, depending on the participants’ level of training adaptation.
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Vavák et al. (2025) conducted an observational in Healthy athletes and general population. Standard training session vs. Control group from the general population was evaluated on Vertical jump performance (jump height and power) (p=<0.05). The AMPD1 CT genotype negatively affected jump height in athletes (p<0.05) and adaptive responses in controls (p<0.001), while ACE II and HIF1A Pro/Ser genotypes increased jump power in controls.
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