Key result
ACTN3, PPARA, and IL6 polymorphisms show no association with aerobic endurance in female volleyball players.
Why the study?
The study was conducted to compare ACTN3 rs1815739, PPARA rs4253778, and IL-6 rs1800795 polymorphisms with aerobic endurance in volleyball players.
Do ACTN3 rs1815739, PPARA rs4253778, and IL6 rs1800795 gene polymorphisms affect aerobic endurance in volleyball players?
Observational (n=22)
Do ACTN3 rs1815739, PPARA rs4253778, and IL6 rs1800795 gene polymorphisms affect aerobic endurance in volleyball players?
ACTN3 rs1815739, PPARA rs4253778, and IL6 rs1800795 gene polymorphisms do not significantly affect aerobic endurance in female volleyball players.
No association in this cohort; leaves open any role for these polymorphisms in aerobic endurance and warrants larger prospective studies.
In this study, we aimed to compare ACTN3 rs1815739, PPARA rs4253778 and IL-6 rs1800795 polymorphisms with aerobic endurance in volleyball players. Twenty-two volleyball players (age: 21.59 ± 2.70 years; height: 1.87 ± 7.92 m; body weight: 80.99 ± 8.14 kg; body fat: 12.05 ± 5.78%) participated in the study voluntarily. DNA extraction from buccal epithelial cells was provided by a commercial kit. Real-Time PCR was performed for genotyping. Statistical analysis of the test results was performed using SPSS 23 (SPSS Inc., Chicago, IL, USA) package program. Homogeneity of variance was analyzed by Levenne test and normal distribution was analyzed by Shapiro-Wilk test. One Way ANOVA Test was used to analyze all parameters. Significance was determined at p0.05). In the findings, no statistically significant difference was detected between the relevant polymorphisms and aerobic performance parameters in our cohort. In conclusion, ACTN3 rs1815739, PPARA rs4253778 and IL6 rs1800795 genes did not create any difference in aerobic endurance in volleyball players. Our results need to be confirmed by further studies.
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SEVER et al. (2025) conducted an observational in Healthy athletes (volleyball players) (n=22). ACTN3 rs1815739, PPARA rs4253778, and IL6 rs1800795 polymorphisms vs. Different genotypes within the same polymorphisms was evaluated on Aerobic endurance measured by Yo-Yo Intermittent Recovery Test 1 (Yo-Yo IRT 1) distance (p=>0.05). ACTN3 rs1815739, PPARA rs4253778, and IL6 rs1800795 gene polymorphisms showed no statistically significant association with aerobic endurance in female volleyball players (p>0.05).
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