Key result
The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to controls, but team sport athletes had a significantly lower frequency of the 577RR genotype than sprint/power athletes (OR 0.26).
Why the study?
Is the ACTN3 R577X polymorphism associated with elite team sport athletic status in Italian male athletes?
Case-Control (n=368)
Is the ACTN3 R577X polymorphism associated with elite team sport athletic status in Italian male athletes?
Odds Ratio: 0.26 (95% CI 0.07–0.95)
Absolute Event Rate: 32% vs 49%
p-value: p=0.044
The ACTN3 R577X polymorphism is not associated with team sport athletic status in Italian males, though the 577RR genotype is more common in sprint/power athletes.
ACTN3 R577X shows no association with team sport status; hypothesis-generating for lower 577RR frequency versus sprint/power athletes.
BACKGROUND: The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes. METHODS: We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy. Genomic DNA was collected using a buccal swab. Extraction was performed according to the manufacturer's directions provided with a commercially available kit (Qiagen S.r.l., Milan, Italy). RESULTS: Team sport athletes showed a lower frequency of the 577RR genotype compared to the 577XX genotype than sprint/power athletes (p = 0.044). However, the ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls. CONCLUSIONS: Our results agree with a recent large-scale study involving athletes from Spain, Poland, and Russia. The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.
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Massidda et al. (2015) conducted a case-control in Athletic status (n=368). ACTN3 R577X polymorphism vs. Sprint/power athletes, endurance athletes, and non-athletic controls was evaluated on 577RR genotype vs 577XX genotype frequency in team sport athletes compared to sprint/power athletes (OR 0.26, 95% CI 0.07-0.95, p=0.044). The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to controls, but team sport athletes had a significantly lower frequency of the 577RR genotype than sprint/power athletes (OR 0.26).
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