Key result
ACTN3 577X homozygote genotype shows no association with elite endurance athlete status versus 577R-allele carriers.
Why the study?
Is the ACTN3 R577X polymorphism associated with elite endurance athlete status in Caucasian males?
Population
620 Caucasian males, comprising 316 elite endurance athletes and 304 sedentary controls from North America…
Comparison
ACTN3 R577X polymorphism and two additional htSNPs vs Sedentary controls matched by country of origin
Design
Case-control
Authors
Loading...
Null association does not support ACTN3 R577X for endurance athlete selection; leaves open roles for other genetic variants.
Case-Control (n=620)
Yes
Is the ACTN3 R577X polymorphism associated with elite endurance athlete status in Caucasian males?
Odds Ratio: 1.24 (95% CI 0.82–1.87)
Absolute Event Rate: 20% vs 17.5%
p-value: p=0.3
The ACTN3 R577X polymorphism is not a genetic determinant of elite endurance performance in Caucasian males.
Döring et al. (2010) conducted a case-control in Elite endurance athlete status (n=620). ACTN3 577X homozygote genotype vs. 577R-allele carriers was evaluated on Elite endurance athlete status (OR 1.24, 95% CI 0.82-1.87, p=0.3). The ACTN3 577X homozygote genotype was not significantly associated with elite endurance athlete status compared with 577R-allele carriers (OR 1.24; 95% CI 0.82-1.87; P=0.3).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: