Key result
In men aged ≥55 years, the ACTN3 XX genotype was associated with lower chair stand test performance compared to the RR (p=0.024) or RX (p=0.005) genotypes.
Why the study?
Is the ACTN3 R577X genotype associated with muscle function in a Japanese population?
Population
1227 Japanese subjects (age: 25-85 years)
Comparison
ACTN3 R577X genotype (RR, RX, XX) vs Comparison between genotypes (XX vs RR vs RX)
Design
Cross-sectional
Authors
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No practice change warranted; hypothesis-generating for ACTN3-muscle function links in older Japanese men.
Observational (n=1,227)
Is the ACTN3 R577X genotype associated with muscle function in a Japanese population?
p-value: p=0.036
The ACTN3 R577X genotype is associated with lower-extremity muscle function in older Japanese men.
Kikuchi et al. (2014) reported an observational. ACTN3 R577X genotype (XX) vs. RR or RX genotype was evaluated on chair stand test performance (p=0.036). In men aged ≥55 years, the ACTN3 XX genotype was associated with lower chair stand test performance compared to the RR (p=0.024) or RX (p=0.005) genotypes.
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