What does this research mean for the field?

Extensive radiofrequency energy application within the pulmonary veins causes significant luminal narrowing or complete occlusion, accompanied by adverse hemodynamic changes and histological damage including intimal proliferation and endovascular contraction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the pathological and hemodynamic consequences of delivering radiofrequency energy within the pulmonary veins.

April 11, 2000CirculationOpen Access

Pathological Effects of Extensive Radiofrequency Energy Applications in the Pulmonary Veins in Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does radiofrequency energy application within the pulmonary veins cause pulmonary vein stenosis and hemodynamic changes in a canine model?

Population

9 anesthetized mongrel dogs

Comparison

Radiofrequency energy application within up to 4… vs Baseline measurements before RF energy application

Design

Preclinical

Follow-up

2 to 14 weeks

Authors

GTGregg W. TaylorThe University of Texas Southwestern Medical Center GKG. Neal KayElectrophysiology XZXiangsheng ZhengUniversity of Shanghai for Science and Technology

Discussion

Member takes

Implication

RF ablation within pulmonary veins may induce stenosis and hemodynamic compromise; extends clinical observations in canines but leaves open safe human ablation parameters.

Key Points

To examine the pathological and hemodynamic consequences of delivering radiofrequency energy within the pulmonary veins.
Performed right heart and transseptal catheterization in 9 anesthetized mongrel dogs with radiofrequency ablation delivered to up to 4 pulmonary veins per subject.
Evaluated hemodynamics and tissue pathology across follow-up intervals of 2 to 4 weeks (n=3), 6 to 8 weeks (n=3), and 10 to 14 weeks (n=3) post-ablation.
Luminal narrowing occurred in 22 of 33 treated pulmonary veins, resulting in 7 complete occlusions, 7 severe stenoses, and 8 minimal narrowings.
Hemodynamic measurements showed significant alterations from baseline in pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, and systemic vascular resistance (P<0.05 for all).
Histology revealed intimal proliferation with organizing thrombi, myocardial necrosis with collagen replacement, endovascular contraction, and elastic lamina proliferation.

Structured PICO

Does radiofrequency energy application within the pulmonary veins cause pulmonary vein stenosis and hemodynamic changes in a canine model?

Population

9 anesthetized mongrel dogs

Intervention

Radiofrequency (RF) energy application within up to 4 separate pulmonary veins

Comparator

Baseline measurements before RF energy application

Outcome

Pathological and hemodynamic effects including pulmonary capillary wedge pressure, cardiac output, pulmonary vascular resistance, systemic vascular resistance, and luminal narrowingsafety

Extensive radiofrequency ablation within pulmonary veins in a canine model causes significant pulmonary vein stenosis and adverse hemodynamic changes.

Cite This Study

Taylor et al. (2000) studied this question.

synapsesocial.com/papers/6a1add28a020f538e68596ed https://doi.org/10.1161/01.cir.101.14.1736

Topics

AF ablation outcomes

View Full Paper

Ask AI

Bookmark

Implication

RF ablation within pulmonary veins may induce stenosis and hemodynamic compromise; extends clinical observations in canines but leaves open safe human ablation parameters.

Pathological Effects of Extensive Radiofrequency Energy Applications in the Pulmonary Veins in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Pathological Effects of Extensive Radiofrequency Energy Applications in the Pulmonary Veins in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider