What does this research mean for the field?

Transient expression of constitutively active Gαq in the heart is sufficient to induce progressive cardiac hypertrophy and dilated cardiomyopathy through both calcineurin-dependent and calcineurin-independent signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand how transient expression of active Gq protein leads to cardiac hypertrophy and dilated cardiomyopathy.

November 10, 1998Proceedings of the National Academy of SciencesOpen Access

Transient cardiac expression of constitutively active Gαqleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

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This research aims to understand how transient expression of active Gq protein leads to cardiac hypertrophy and dilated cardiomyopathy.
Transgenic mice expressed hemagglutinin-tagged, constitutively active Gq protein.
Assessment of cardiac morphology and function over 10 weeks.
Use of cyclosporin A to analyze effects on hypertrophy and signaling pathways.
Transient expression of active Gq induced hypertrophy and dilatation, with progression lasting 30 weeks until heart failure.
Increased PLC activity observed in atria (9-10 fold) by 2 weeks; later elevated in ventricles as well.
Cyclosporin A treatment reduced some hypertrophic symptoms, indicating involvement of multiple signaling pathways.

Structured PICO

Population

Transgenic mice with transient cardiac expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the Gq alpha subunit (HAalpha*q)

Intervention

Transient expression of HAalpha*q; subset treated with Cyclosporin A (CsA)

Comparator

Untreated HAalpha*q mice (for the Cyclosporin A intervention)

Outcome

Development of cardiac hypertrophy and dilatationsurrogate

Transient activation of Gq signaling in the heart is sufficient to initiate a progressive hypertrophic and dilated cardiomyopathy phenotype that is maintained by compensatory pathways and only partially rescued by calcineurin inhibition.

Discussion

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Implication

Transient Gq activation suffices for progressive cardiomyopathy in mice; leaves open human translation and calcineurin-targeted therapies.

Cite This Study

Mende et al. (1998) studied this question.

synapsesocial.com/papers/6a1adfa49fa30811a0b93b5d https://doi.org/10.1073/pnas.95.23.13893

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Implication

Transient Gq activation suffices for progressive cardiomyopathy in mice; leaves open human translation and calcineurin-targeted therapies.

Transient cardiac expression of constitutively active Gαqleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Transient cardiac expression of constitutively active Gαqleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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