Key result
Higher post-challenge insulin (30-min insulin AUC) was inversely associated with NT-proANP concentrations in African American adults, which may contribute to their lower ANP concentrations.
Why the study?
African American individuals have lower natriuretic peptide levels and a higher burden of type 2 diabetes, prompting investigation into whether higher post-challenge insulin associates with lower NT-proANP.
Cross-Sectional (n=112)
Higher post-challenge insulin is inversely associated with NT-proANP in African American adults, suggesting a potential mechanism for their lower natriuretic peptide levels and higher risk of Type 2 diabetes.
Hypothesis-generating for insulin-ANP links in African Americans; prospective studies needed before any clinical implications.
Low concentrations of natriuretic peptides (NPs) have been associated with greater risk for Type 2 diabetes (T2D). African American individuals (AA) have lower NP levels and are disproportionately burdened by T2D. The purpose of this study was to test the hypothesis that higher post-challenge insulin in AA adults is associated with lower plasma N-terminal pro-atrial natriuretic peptide (NT-proANP). A secondary purpose was to explore associations between NT-proANP and adipose depots. Participants were 112 AA and European American (EA) adult men and women. Measures of insulin were obtained from an oral glucose tolerance test and hyperinsulinemic-euglycemic glucose clamp. Total and regional adipose depots were measured from DXA and MRI. Multiple linear regression analysis was used to assess associations of NT-proANP with measures of insulin and adipose depots. Lower NT-proANP concentrations in AA participants was not independent of 30-min insulin area under the curve (AUC). NT-proANP was inversely associated with 30-min insulin AUC in AA participants, and with fasting insulin and HOMA-IR in EA participants. Thigh subcutaneous adipose tissue and perimuscular adipose tissue were positively associated with NT-proANP in EA participants. Higher post-challenge insulin may contribute to lower ANP concentrations in AA adults.
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Couch et al. (2023) conducted a cross-sectional in Insulin resistance and adipose depots (n=112). NT-proANP was evaluated on Associations of NT-proANP with measures of insulin and adipose depots. Higher post-challenge insulin (30-min insulin AUC) was inversely associated with NT-proANP concentrations in African American adults, which may contribute to their lower ANP concentrations.
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