Corticosteroid Therapy for Diffuse Alveolar Hemorrhage in Autologous Bone Marrow Transplant Recipients

Brief Reports15 January 1991Corticosteroid Therapy for Diffuse Alveolar Hemorrhage in Autologous Bone Marrow Transplant RecipientsNelson J. Chao, MD, Steven R. Duncan, MD, Gwynn D. Long, MD, Sandra J. Horning, MD, Karl G. Blume, MDNelson J. Chao, MDSearch for more papers by this author, Steven R. Duncan, MDSearch for more papers by this author, Gwynn D. Long, MDSearch for more papers by this author, Sandra J. Horning, MDSearch for more papers by this author, Karl G. Blume, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-2-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRobbins and colleagues (1) recently reported a syndrome of diffuse alveolar hemorrhage seen in patients after autologous bone marrow transplantation. This entity was noted in 29 of 141 patients (21%) and was associated with an 80% mortality rate (23 of the 29 patients died). Risk factors associated with the development of this syndrome included age over 40 years, underlying solid tumors, high fevers, severe mucositis, leukocyte recovery, and renal insufficiency. The Memorial Sloan-Kettering group (2) also recently reported their experience with pulmonary complications after autologous bone marrow transplantation. Pulmonary hemorrhage was seen 11 of 31 patients (35%) receiving transplants for...References1. RobbinsLinderStahl RJM. Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Am J Med. 1989;87:511-8. CrossrefMedlineGoogle Scholar2. Jules-ElyseeGulatiStoverWhite KSDD. Pulmonary complications in autologous bone marrow transplantation [Abstract]. Am Rev Respir Dis. 1990;141:A604. Google Scholar3. LeathermanDaviesHoidal JSJ. Alveolar hemorrhage syndromes: diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine. 1984;63:343-61. CrossrefMedlineGoogle Scholar4. KahnJonesEngland FJD. Diagnosis of pulmonary hemorrhage in the immunocompromised host. Am Rev Respir Dis. 1987;136:155-60. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Stanford University Medical Center, Stanford, California. For current author addresses, see end of text. 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