Key result
Bariatric surgery is linked to a sharp first-month HDL drop, indicating transiently increased cardiovascular risk.
Why the study?
Because obesity and overweight are strongly associated with cardiovascular diseases, this study investigated cardiovascular events risk in individuals who lost weight through bariatric surgery.
Does bariatric surgery alter surrogate markers of cardiovascular risk in patients with obesity over a 6-month follow-up?
Cohort
Does bariatric surgery alter surrogate markers of cardiovascular risk in patients with obesity over a 6-month follow-up?
p-value: p=<0.0001
Bariatric surgery is associated with a transient worsening of atherogenic lipid profiles in the first month postoperatively, highlighting a period of potentially increased cardiovascular risk before long-term improvement.
Highlights potential early CV risk after bariatric surgery; leaves open effects on hard outcomes in observational data.
Objectives: Since obesity and overweight are strongly associated with cardiovascular diseases, we investigated cardiovascular events risk in individuals who lost weight through bariatric surgery. Methods: Serum levels of glucose, insulin, triacylglycerol, HDL cholesterol, non-HDLDL cholesterol, and lipoprotein ratios were assessed in patients with obesity before and after bariatric surgery, including a 6-month follow-up period. Results: Bariatric surgery significantly improved BMI, triglyceride levels, glucose, and insulin sensitivity. However, HDL cholesterol levels dropped sharply in the first month (p < 0.0001), coinciding with elevated atherogenic indices, indicating a transient increase in cardiovascular risk. By 6 months, indices improved significantly, HDL recovered, and LDL particle size increased, suggesting reduced atherogenic potential. Conclusions: Individuals undergoing bariatric surgery have a higher cardiovascular events risk in the immediate postoperative period. Health professionals should be aware of and monitor these patients closely.
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Bratti et al. (2025) conducted a cohort in Obesity. Bariatric surgery vs. Pre-surgery baseline was evaluated on Serum levels of glucose, insulin, triacylglycerol, HDL cholesterol, non-HDLDL cholesterol, and lipoprotein ratios (p=<0.0001). Bariatric surgery was associated with a sharp drop in HDL cholesterol in the first month (p < 0.0001) and elevated atherogenic indices, indicating a transient increase in cardiovascular risk.
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