Why the study?
Obesity is a predisposing factor for serious comorbidities related to elevated cardiovascular mortality, and the study aimed to assess cardiovascular risk before and after surgical treatment of obesity.
Does bariatric surgery improve the atherogenic index of plasma (AIP) in patients with severe obesity?
Cohort (n=615)
No
Does bariatric surgery improve the atherogenic index of plasma (AIP) in patients with severe obesity?
Absolute Event Rate: 11.4% vs 56.2%
p-value: p=<0.001
Bariatric surgery significantly reduces the atherogenic index of plasma, a surrogate marker for insulin resistance and cardiovascular risk, with effects persisting up to 3 years postoperatively.
Bariatric surgery was associated with AIP reduction in severe obesity; hypothesis-generating for CV risk reduction, requiring RCT confirmation before practice change.
BACKGROUND: Obesity is a predisposing factor for serious comorbidities, particularly those related to elevated cardiovascular mortality. The atherogenic index of plasma (AIP) has been shown to be a useful indicator of patients with insulin resistance. AIMS: The aim of this study was to assess cardiovascular risk before and after surgical treatment of obesity. METHODS: A total of 615 patients undergoing bariatric surgery between 2007 and 2012 were evaluated using the analysis of electronic records (triglyceride/high-density lipoprotein cholesterol) before and after surgery. The AIP levels >3.5 mg/dL for men and >2.5 mg/dL for women were insulin-resistant and predisposed to cardiovascular events. RESULTS: A total of 117 men had an AIP >3.5 mg/dL during the preoperative period, 13.5% during the early postoperative period, 14.3% during the intermediate period, and 18.2% during the late postoperative period. Among 498 women, 56.2% had an AIP >2.5 mg/dL before surgery, 17.9% in early postoperative period, 13.5% in the intermediate period, and 11.4% in the late period. CONCLUSIONS: Bariatric surgery resulted in a significant effect on the AIP, insulin resistance, metabolic syndrome, and therefore, the risk of cardiovascular diseases.
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Cardia et al. (2024) conducted a cohort in Severe obesity (n=615). Bariatric surgery vs. Preoperative baseline was evaluated on High atherogenic index of plasma in women (AIP >2.5 mg/dL) at late postoperative period (p=<0.001).
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