Key result
Women with a history of very irregular menstrual cycles had a significantly increased risk for nonfatal or fatal CHD compared to those with very regular cycles (RR 1.67; 95% CI 1.35-2.06).
Why the study?
Does a history of irregular menstrual cycles increase the risk of incident coronary heart disease and stroke in women?
Population
82,439 female nurses who provided information on prior menstrual regularity (at ages 20-35 yr)
Comparison
History of usually irregular or very irregular… vs History of very regular menstrual cycles
Design
Cohort
Follow-up
14 yr
Authors
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Irregular menses history may flag higher CHD risk in women; leaves open utility for risk stratification or causal interventions.
Cohort (n=82,439)
Does a history of irregular menstrual cycles increase the risk of incident coronary heart disease and stroke in women?
Effect estimate: RR 1.67 (95% CI 1.35-2.06)
A history of irregular menstrual cycles in young adulthood is associated with an increased risk of future coronary heart disease, suggesting it may serve as a marker for metabolic abnormalities predisposing to CVD.
C. G. Solomon (2002) conducted a cohort in Cardiovascular disease (n=82,439). Irregular menstrual cycles vs. Very regular menstrual cycles was evaluated on Nonfatal or fatal CHD (RR 1.67, 95% CI 1.35-2.06). Women with a history of very irregular menstrual cycles had a significantly increased risk for nonfatal or fatal CHD compared to those with very regular cycles (RR 1.67; 95% CI 1.35-2.06).
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