Early menarche was associated with coronary artery disease (OR 1.60; 95% CI 1.11-2.31) compared to other CVD diagnoses among females with established cardiovascular disease.
Cross-Sectional (n=2,228)
No
Are female-specific reproductive and hormonal factors associated with specific cardiovascular disease subtypes in females with established CVD?
Female-specific reproductive and hormonal factors differ significantly across various cardiovascular disease subtypes, highlighting the need to incorporate these histories into cardiovascular risk assessment.
Odds Ratio: 1.6 (95% CI 1.11–2.31)
Background Female-specific factors may influence cardiovascular disease (CVD) risk; however, their distribution across different CVD diagnoses is not well characterized. This study examined associations between female-specific health factors and CVD subtype among females with established CVD. Methods This cross-sectional study included females aged ≥18 years with a diagnosis of CVD who had received care at the University of Ottawa Heart Institute between June 2022 and December 2023. Participants were categorized by primary diagnosis: arrhythmia, coronary artery disease (CAD), cardiomyopathy, congenital heart disease, heart failure, valvular heart disease, peripheral vascular disease, or cerebrovascular disease. We examined the associations between female-specific factors and each diagnosis compared with all other CVD diagnoses and adjusted for age. Results Among the 2,228 respondents, the most common diagnoses were arrhythmia (30.8%) and CAD (27.7%). Early menarche was more common among participants with CAD (OR 1.60, 95% CI 1.11–2.31). Irregular menstrual cycles were more common among females with congenital heart disease (OR 1.43, 95% CI 1.01–2.02). Females with CAD also had greater odds of gestational diabetes (OR 1.94, 95% CI 1.29–2.90), hypertensive disorders of pregnancy (OR 1.52, 95% CI 1.08–2.12), and premature menopause (OR 1.36, 95% CI 1.01–1.83). Migraine was associated with peripheral vascular disease (OR 1.97, 95% CI 1.18–3.29), while vasomotor menopausal symptoms were frequently reported by females with cerebrovascular disease (OR 2.45, 95% CI 1.10–5.49). Conclusions Female-specific reproductive and hormonal factors differed across CVD diagnoses among females with established CVD. These findings highlight the importance of incorporating reproductive and hormonal history into cardiovascular risk assessment and support the need for further research on sex-specific pathways underlying different CVD subtypes.
Goulets et al. (Wed,) conducted a cross-sectional in Cardiovascular disease (n=2,228). Female-specific reproductive and hormonal factors (e.g., early menarche) vs. All other cardiovascular disease diagnoses was evaluated on Association of early menarche with coronary artery disease (OR 1.60, 95% CI 1.11-2.31). Early menarche was associated with coronary artery disease (OR 1.60; 95% CI 1.11-2.31) compared to other CVD diagnoses among females with established cardiovascular disease.