Key result
CNA35-GP@NPs enable multimodal imaging of post-MI fibrosis in rats, correlating signal intensity with fibrosis severity.
Why the study?
Inadequate early diagnostic methods hinder prompt treatment of myocardial fibrosis, as current imaging modalities face limitations in resolution, tissue differentiation, or patient eligibility.
Does CNA35-GP@NPs enable multimodal imaging and quantification of myocardial fibrosis in a rat model of myocardial infarction?
Does CNA35-GP@NPs enable multimodal imaging and quantification of myocardial fibrosis in a rat model of myocardial infarction?
A novel collagen-targeted nanoplatform enables multimodal (ultrasound, photoacoustic, CT) imaging and quantification of post-infarction myocardial fibrosis in a rat model.
May aid preclinical fibrosis imaging in rodent MI; leaves open human translation.
Currently, inadequate early diagnostic methods hinder the prompt treatment of patients with heart failure and myocardial fibrosis. Magnetic resonance imaging is the gold standard noninvasive diagnostic method; however, its effectiveness is constrained by low resolution and challenges posed by certain patients who cannot undergo the procedure. Although enhanced computed tomography (CT) offers high resolution, challenges arise owing to the unclear differentiation between fibrotic and normal myocardial tissue. Furthermore, although echocardiography is real-time and convenient, it lacks the necessary resolution for detecting fibrotic myocardium, thus limiting its value in fibrosis detection. Inspired by the postinfarction accumulation of collagen types I and III, we developed a collagen-targeted multimodal imaging nanoplatform, CNA35-GP@NPs, comprising lipid nanoparticles (NPs), encapsulating gold nanorods (GNRs) and perfluoropentane (PFP). This platform facilitated ultrasound/photoacoustic/CT imaging of postinfarction cardiac fibrosis in a rat model of myocardial infarction (MI). The surface-modified peptide CNA35 exhibited excellent collagen fiber targeting. The strong near-infrared light absorption and substantial X-ray attenuation of the nanoplatform rendered it suitable for photoacoustic and CT imaging. In the rat model of MI, our study demonstrated that CNA35-GNR/PFP@NPs (CNA35-GP@NPs) achieved photoacoustic, ultrasound, and enhanced CT imaging of the fibrotic myocardium. Notably, the photoacoustic signal intensity positively correlated with the severity of myocardial fibrosis. Thus, this study presents a promising approach for accurately detecting and treating the fibrotic myocardium.
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Li et al. (2024) studied Myocardial fibrosis in myocardial infarction. CNA35-GP@NPs (collagen-targeted multimodal imaging nanoplatform) was evaluated on Detection and quantification of myocardial fibrosis using ultrasound, photoacoustic, and CT imaging. CNA35-GP@NPs achieved multimodal imaging of fibrotic myocardium in a rat model of myocardial infarction, with photoacoustic signal intensity positively correlating with fibrosis severity.
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