Key result
Obesity-resistant rats fed a high-fat diet developed cardiac remodeling that was not related to changes in collagen type I and III protein expression.
Why the study?
It was unclear whether cardiac remodeling in individuals resistant to obesity development is related to changes in collagen protein expression.
Does obesity resistance in rats fed a high-fat diet prevent cardiac remodeling and changes in collagen I and III protein expression compared to control?
Does obesity resistance in rats fed a high-fat diet prevent cardiac remodeling and changes in collagen I and III protein expression compared to control?
In a rat model, obesity resistance during high-fat diet feeding does not prevent cardiac remodeling, and this remodeling occurs independently of changes in collagen I and III protein expression.
Answers are grounded in this paper and cite their sources.
Obesity resistance may not confer cardiac protection in diet models; leaves open collagen-independent remodeling mechanisms for human studies.
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Oliveira et al. (2021) studied Obesity and Cardiac Remodeling (n=30). High-fat diet (HFD) vs. Control diet (CD) was evaluated on Cardiac remodeling and collagen type I and III protein expression. Obesity-resistant rats fed a high-fat diet developed cardiac remodeling that was not related to changes in collagen type I and III protein expression.
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